血管内皮祖细胞与糖尿病微血管病变研究进展

糖尿病微血管病变严重影响了患者生活质量,是患者致死致残主要原因。微血管病变主要表现在视网膜、肾、神经、心肌组织。微血管病变的机制尚未完全清楚,近年越来越多研究发现血管内皮祖细胞(endothelial progenitor cells,EPCs)是该病发病重要原因。EPCs有分化为成熟的内皮细胞并且参与新血管形成和新生的能力。正常情况下内皮损失和EPCs对内皮的修复作用处于动态平衡状态,一旦EPCs受损,内皮损害和修复之间的平衡被打破,内皮层的完整性遭到破坏,必然参与糖尿病血管病变的发生发展。国内外大量研究证明糖尿病合并大血管病变EPCs数目功能改变,而糖尿病合并微血管病变EPCs的怎样变化?本文就EPCs与糖尿病微血管病变的关系进行系统综述。

Advance in Endothelial Progenitor Cells and DiabeticMicroangiopathy

Diabetic microangiopathy,which is a main cause leading to death and disability,seriously affected the quality of life in patients.Microvascular disease are mainly expressed in the retina,kidney,nerve,cardiac tissue.Microvascular mechanisms has not entirely clear and in recent years more and more study show that endothelial progenitor cells(endothelial progenitor cells,EPCs) is the important reason related to this diseases.EPCs have the ability to differentiate into mature endothelial cells and participate in the formation and the newborn of the new blood vessels.Normally endothelial damage and the function of EPCs to endothelial repair is in a state of dynamic balance,and once EPCs is damaged,the balance between endothelial damage and restoration is broken,the integrity of the endothelial layer is also compromised,which inevitably involved in the occurrence and development of diabetic angiopathy.Numerous studies at home and abroad prove that diabetes,which is combinated to macroangiopathy,lead to the change about the number and function of EPCs.however,how about the changes about the combination of diabetic and microangiopathy EPCs? This article will sysmaticly describes the relations between EPCs and diabetic microvascular disease.