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超声引导下局部注射甲氨蝶呤治疗异位妊娠的临床应用
引用本文:姬宏娟汪龙霞,王军燕徐虹高学文林倩周春艳.超声引导下局部注射甲氨蝶呤治疗异位妊娠的临床应用[J].现代生物医学进展,2012,12(3):476-478.
作者姓名:姬宏娟汪龙霞  王军燕徐虹高学文林倩周春艳
作者单位:解放军总医院超声科 北京100853
摘    要:目的:探讨超声引导下局部注射甲氨蝶呤(MTX)治疗异位妊娠的疗效。方法:对30例异位妊娠患者在超声引导下行MTX病灶局部注射,术后给予米非司酮口服(25mg,2次/天,共3天)。治疗前及治疗后每周一次抽血查β-hCG直至其降至正常范围内。结果:30例患者中,29例(96.7%)通过治疗后β-hCG降至正常,1例(3.3%)治疗失败后行外科手术。结论:超声引导下MTX局部注射治疗异位妊娠技术操作简单,疗效肯定,对适应范围内的病人是值得考虑的治疗方法。

关 键 词:超声引导  异位妊娠  甲氨蝶呤  局部注射

The Clinical Application of Ultrasound-Guided Methotrexate Injection in Patients with Ectopic Pregnancy
JI Hong-juan,WANG Long-xi,WANG Jun-yan,XU Hong,GAO Xue-wen,LIN Qian,ZHOU Chun-Yan.The Clinical Application of Ultrasound-Guided Methotrexate Injection in Patients with Ectopic Pregnancy[J].Progress in Modern Biomedicine,2012,12(3):476-478.
Authors:JI Hong-juan  WANG Long-xi  WANG Jun-yan  XU Hong  GAO Xue-wen  LIN Qian  ZHOU Chun-Yan
Institution:(Department of Ultrasound,Chinese PLA General Hospital,Beijing 100853,China)
Abstract:Objective: To evaluate the efficacy and safety of methotrexate(MTX) injection for ectopic pregnancy under ultrasound-guidance.Methods: 30 patients with ectopic pregnancy were treated with MTX injection under ultrasound-guidance followed by administration of mifepristone for 3 days(25mg,bid).Serum level of β-hCG was tested before treatment and then once a week after MTX injection.Results: 2-12weeks after MTX injection,β-hCG turned to be negative in 29 patients(96.7%).1 patient(3.3%) received operation because of the rupture lesion.Conclusion: Within considerable indication,MTX injection under ultrasound-guidance is effective and safe for patients with ectopic pregnancy.
Keywords:Ultrasound-guidance  Ectopic pregnancy  Methotrexate  Local injection
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