Neutral two-locus multiple allele models with recombination |
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Authors: | RC Griffiths |
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Institution: | Department of Mathematics, Monash University, Clayton, Victoria, Australia |
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Abstract: | General formulae for the homozygosity and variance of linkage disequilibrium are derived for neutral, stationary, two-locus multiple allele models where there is a symmetric type of mutation at each locus. Particular cases examined are K allele models, the infinite alleles model, and the stepwise mutation model. The two-locus infinite allele model is examined at the molecular level and a joint probability generating function is found for the number of heterozygous sites at each locus in two randomly chosen gametes. |
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