Catecholamines and dopamine-β-hydroxylase activity during therapeutic abortion induced by sulprostone |
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Authors: | S. Saarikoski K. Selander E. Nukala P. Pystynen |
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Affiliation: | 1. Department of Clinical Sciences, University of Tampere, Teiskontie 35, SF-33520 Tampere 52, Finland;2. Department of Obstetrics and Gynaecology, University Hospital of Tampere, SF-33520 Tampere 52, Finland;3. Department of Biomedical Sciences, University of Tampere, Lääkärinkatu 3, SF-33520 Tampere 52, Finland |
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Abstract: | To evaluate the changes in circulating norepinephrine (NE), epinephrine (E) and dopamine-β-hydroxylase (DBH) caused by an intravenous infusion of a derivate of PGE2, sulprostone, in connection with legal termination of pregnancy, serial plasma samples were analyzed for six gravidae. Plasma catecholamines were measured by a sensitive radioenzymatic method (9,10) and DBH activities by a photometric assay (11). Intravenous infusion of sulprostone, in abortifacient doses as an intravenous infusion of 3–4 μg per minute for six to eight hours produced a decrease in circulating norepinephrine. No significant alteration was found in plasma epinephrine or dopamine-β-hydroxylase activity. The finding suggests an inhibitory effect of sulprostone on the release of norepinephrine from the adrenergic terminals without inhibition of the adrenal medulla. |
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