首页 | 本学科首页   官方微博 | 高级检索  
   检索      


Aflatoxin-lysine adducts in blood serum of the Malawian rural population and aflatoxin contamination in foods (groundnuts,maize) in the corresponding areas
Authors:Anitha Seetha  Emmanuel S Monyo  Takuji W Tsusaka  Harry W Msere  Frank Madinda  Tiyamika Chilunjika  Ethel Sichone  Dickson Mbughi  Benson Chilima  Limbikani Matumba
Institution:1.International Crops Research Institute for the Semi-Arid Tropics (ICRISAT),Lilongwe,Malawi;2.International Crops Research Institute for the Semi-Arid Tropics (ICRISAT),Hyderabad,India;3.Arusha Lutheran Medical Center,Arusha,Tanzania;4.Kamuzu Central Hospital,Lilongwe,Malawi;5.Food and Agricultural Organization (FAO),Lilongwe,Malawi;6.Community Health Sciences Unit (CHSU),Lilongwe,Malawi;7.Food Technology and Nutrition Group,Lilongwe University of Agriculture and Natural Resources,Lilongwe,Malawi
Abstract:Aflatoxin-lysine (AFB1-lys) adduct levels in blood samples collected from 230 individuals living in three districts of Malawi (Kasungu, Mchinji, and Nkhotakota) and aflatoxin B1 (AFB1) levels in groundnut and maize samples collected from their respective homesteads were determined using indirect competitive enzyme-linked immunosorbent assay (IC-ELISA) methods. AFB1-lys adducts were detected in 67% of blood samples, with a mean concentration of 20.5?±?23.4 pg/mg of albumin. AFB1 was detected in 91% of groundnut samples and in 70% of maize samples, with mean AFB1 levels of 52.4 and 16.3 μg/kg, respectively. All participants of this study reported consuming maize on a daily basis and consuming groundnuts regularly (mean consumption frequency per week: 3.2?±?1.7). According to regression analysis, a frequency of groundnut consumption of more than four times per week, being female, and being a farmer were significant (p?<?0.05) contributors to elevated AFB1-lys adduct levels in the blood. This is the first report on AFB1-lys adducts in blood samples of residents in Malawi. The results reinforce the urgent need for interventions, aiming at a reduction of aflatoxin exposure of the population.
Keywords:
本文献已被 SpringerLink 等数据库收录!
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号