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Tuning ion channel mechanosensitivity by asymmetry of the transbilayer pressure profile |
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| Authors: | Boris Martinac Navid Bavi Pietro Ridone Yury A Nikolaev Adam D Martinac Yoshitaka Nakayama Paul R Rohde Omid Bavi |
| Institution: | 1.Victor Chang Cardiac Research Institute,Darlinghurst,Australia;2.St Vincent’s Clinical School,University of New South Wales,Darlinghurst,Australia;3.Institute for Biophysical Dynamics,University of Chicago,Chicago,USA;4.Dept. of Cellular & Molecular Physiology,Yale University,New Haven, CT 06520-8026,USA;5.NeuRA,Randwick,Australia;6.Institute for Nanoscience and Nanotechnology, Department of Mechanical and Aerospace Engineering,Shiraz University of Technology,Shiraz,Iran |
| Abstract: | Mechanical stimuli acting on the cellular membrane are linked to intracellular signaling events and downstream effectors via different mechanoreceptors. Mechanosensitive (MS) ion channels are the fastest known primary mechano-electrical transducers, which convert mechanical stimuli into meaningful intracellular signals on a submillisecond time scale. Much of our understanding of the biophysical principles that underlie and regulate conversion of mechanical force into conformational changes in MS channels comes from studies based on MS channel reconstitution into lipid bilayers. The bilayer reconstitution methods have enabled researchers to investigate the structure-function relationship in MS channels and probe their specific interactions with their membrane lipid environment. This brief review focuses on close interactions between MS channels and the lipid bilayer and emphasizes the central role that the transbilayer pressure profile plays in mechanosensitivity and gating of these fascinating membrane proteins. |
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