Genetic regulation of testosterone-induced immune suppression |
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| Authors: | S A Ahmed N Talal P Christadoss |
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| Affiliation: | 1. Center for Biomedical Research, Population Council, 1230 York Avenue, New York, NY, USA;2. Department of Endocrinology, Institute of Zoology, Jagiellonian University, Gronostajowa 9, 30-387 Krakow, Poland;1. The Department of Pediatric Surgery, Rigshospitalet, DK-2100 Copenhagen;2. Section of Endocrinology, Department of Pediatrics, Hvidovre University Hospital, Copenhagen;3. Faculty of Health Science, University of Copenhagen;4. Department of Pathology, Rigshospitalet, Copenhagen;5. Douglas Stephens Surgical Research Laboratory, Murdoch Childrens Research Institute, Melbourne, Australia;6. Department of Paediatric Urology, Royal Children’s Hospital, Melbourne, Australia;7. Department of Paediatrics, University of Melbourne |
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| Abstract: | Genes in the major histocompatibility complex (H-2) of the mouse control several immune functions as well as various facets of testosterone (Te) physiology. In order to study the genetic control of Te-induced immune suppression, complete Freund's adjuvant (CFA; containing Mycobacteria tuberculosis) was administered parenterally to several mouse strains differing at the H-2 complex which were either sham- or Te-treated. The specific lymphocyte proliferative response to purified protein derivative (PPD) was measured in draining lymph node cells. The response to PPD in strains bearing H-2b (B6 and B10) but not H-2d (B10.D2 and DBA/2) or H-2k (B10.BR and AKR) haplotypes was markedly lower in Te-implanted compared to sham-implanted controls. This result suggests that the ability of Te to dampen the immune response to PPD is regulated by H-2-linked gene(s). |
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