Distribution of lead in human milk fractions |
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Authors: | Alexandra da Silva Anastácio Carmem Lucia Porto da Silveira Norbert Miekeley Carmen Marino Donangelo |
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Institution: | Departamento de Bioquímica, Instituto de Química, Universidade Federal do Rio de Janeiro, CT, Bloco A, 528, 21949-900 Rio de Janeiro, Brazil. |
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Abstract: | The purpose of this study was to determine the concentration and distribution of lead, calcium, iron, zinc, and copper in
major fractions (fat, casein, whey) of mature milk from 38 nursing adult women with low environmental lead exposure. The potential
associations between milk lead and maternal blood lead and between milk and blood lead and essential mineral data (nutritional
status, dietary intake, and milk concentration) were investigated. Maternal blood lead (geometric mean, 60 μg/L) was negatively
associated, although modestly, with dietary calcium intake (r=−0.32, p=0.02). Lead in whole milk (geometric mean, 1.2 μg/L) was positively associated with calcium in whole milk (r=0.56, p=0.005). Distribution of lead in milk fractions was 63%, 28%, and 9%, in whey, fat, and casein, respectively. Milk distribution
of essential minerals was 67–76%, 17–18%, and 7–17% in whey, fat, and casein, respectively. Lead in milk whey was positively
associated with lead in maternal blood (r=0.49, p=0.02). However, milk lead was not affected by nutritional status, dietary intake, and milk composition of the essential minerals.
The high percentage of lead in the milk whey fraction, as seen for the essential minerals, suggests that most lead in human
milk is bioavailable to the infant. |
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Keywords: | Lead calcium breast milk milk compartments mineral nutritional status |
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