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Integrin triplets of marine sponges in human D2 receptor heteromers
Abstract:The evidence for the existence of receptor heteromers opens up a new field for a better understanding of neural transmission. Based on our theory, we have discovered main triplets of amino acid residues in cell-adhesion receptors of marine sponges, which appear also as homologies in several dopamine D2 receptor heteromers of human brain. The obtained results probably mean a general molecular mechanism for receptor–receptor interactions in heteromers originated from the lowest animals (marine sponges).
Keywords:Dopamine D2 receptor  receptor–receptor interactions  marine sponges
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