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The utility of naphthyl-keratin adducts as biomarkers for jet-fuel exposure |
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| Abstract: | We investigated the association between biomarkers of dermal exposure, naphthyl-keratin adducts (NKA), and urine naphthalene biomarker levels in 105 workers routinely exposed to jet-fuel. A moderate correlation was observed between NKA and urine naphthalene levels (p?=?0.061). The NKA, post-exposure breath naphthalene, and male gender were associated with an increase, while CYP2E1*6 DD and GSTT1-plus (++/+?) genotypes were associated with a decrease in urine naphthalene level (p? |
| Keywords: | Biomarkers CYP2E1 dermal exposure glutathione S-transferase mu 1 (GSTM1) glutathione S-transferase theta 1 (GSTT1) jet fuel (JP-8) keratin adduct NAD(P)H:quinone oxidoreductase (NQO1) 1-naphthol 2-naphthol naphthalene urine |