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A Primer on the Bayesian Approach to High-Density Single-Molecule Trajectories Analysis
Authors:Mohamed El?Beheiry  Silvan Türkcan  Maximilian?U Richly  Antoine Triller  Antigone Alexandrou  Maxime Dahan  Jean-Baptiste Masson
Abstract:Tracking single molecules in living cells provides invaluable information on their environment and on the interactions that underlie their motion. New experimental techniques now permit the recording of large amounts of individual trajectories, enabling the implementation of advanced statistical tools for data analysis. In this primer, we present a Bayesian approach toward treating these data, and we discuss how it can be fruitfully employed to infer physical and biochemical parameters from single-molecule trajectories.
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