Influence of a Dorsomedial Hypothalamus Lesion on the Circadian Changes in the Enzyme Development and Activity of Intestinal Brushborder Membranes in the Rat |
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| Authors: | W. Th J. M. Hekkens P. A. Van Rijn J. Luka
-bajalo R. Ungerer W. J. Rietveld |
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| Affiliation: | a Department of Physiology and Physiological Physics, University of Leiden, Wassenaarseweg, Leiden, The Netherlandsb University Clinical Centre, Pediatric Clinic Ljubljana, Ljubljana, Yugoslavia |
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| Abstract: | Circadian changes in activities and electrophoretic pattern of the intestinal brushborder enzymes alkaline phosphatase (EC 3.1.3.1), isomaltase (EC 3.2.1.10) and sucrase (EC 3.2.1.26) of normal rats and of rats with a lesion of the dorsomedial hypothalamus (DMH-rats) were studied. In contrast to the rhythm found in normal rats, there are no significant differences between the average enzyme activities in the light or dark period for the DMH-rats. The peak ratio in the electrophoretic pattern for sucrase-isomaltase (SI) over pro-sucrase-isomaltase (pro-SI) changes over 24 hr with higher values during the active (dark) period of the normal rat. In DMH-rats this ratio is much higher, but no significant difference could be demonstrated between the values near the acrophase in these rats. |
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| Keywords: | Circadian rhythms membrane analysis dorsomedial hypothalamus intestine sucrase-isomaltase alkaline phosphatase rat |
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