Immune responses and immunotherapeutic interventions in malignant pleural mesothelioma |
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Authors: | Adam J Bograd Kei Suzuki Eva Vertes Christos Colovos Eduardo A Morales Michel Sadelain Prasad S Adusumilli |
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Institution: | (1) Division of Thoracic Surgery, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA;(2) Center for Cell Engineering, Memorial Sloan-Kettering Cancer Center, New York, NY, USA; |
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Abstract: | Malignant pleural mesothelioma (MPM) is an aggressive, primary pleural malignancy with poor prognosis, hypothesized to originate
from a chronic inflammatory state within the pleura. Similar to what has been observed in other solid tumors (melanoma, ovarian
and colorectal cancer), clinical and pre-clinical MPM investigations have correlated anti-tumor immune responses with improved
survival. As such, a better understanding of the complex MPM tumor microenvironment is imperative in strategizing successful
immunotherapies. Herein, we review the immune responses vital to the development and progression of MPM, as well as assess
the role of immunomodulatory therapies, highlighting recent pre-clinical and clinical immunotherapy investigations. |
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