A refined synthesis of enantiomerically pure 2-aminocyclobutanecarboxylic acids |
| |
Authors: | Valérie Declerck David J Aitken |
| |
Institution: | 1.Laboratoire de Synthèse Organique et Méthodologie,ICMMO (UMR 8182-CNRS), Université Paris-Sud 11,Orsay Cedex,France |
| |
Abstract: | The synthesis of enantiomerically pure 2-aminocyclobutanecarboxylic acids has been refined to improve both the efficiency
and the simplicity. These improvements provide a shorter and easier access to the racemic cis-cyclobutane β-amino acid core. Derivatization of this material with a chiral non-racemic oxazolidin-2-one allows easy diastereoisomeric
separation and presents the advantage of allowing the non-destructive cleavage of the chiral auxiliary either by hydrolysis
or by ammonolysis, thus providing an efficacious access to N-protected derivatives of all four stereoisomers of Boc-2-aminocyclobutanecarboxylic
acid. |
| |
Keywords: | |
本文献已被 PubMed SpringerLink 等数据库收录! |