Glycomics-driven discoveries in schistosome research |
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Authors: | Hokke Cornelis H Deelder André M Hoffmann Karl F Wuhrer Manfred |
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Affiliation: | Department of Parasitology, Leiden University Medical Center, P.O. Box 9600, 2300 RC Leiden, The Netherlands. c.h.hokke@lumc.nl |
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Abstract: | Schistosome glycans and glycoconjugates play a prominent role in the parasite's biology, in particular in the interaction with the human host. A large amount of structural data regarding glycosylation of different schistosome life stages and glycoconjugate subsets has been collected in the last decade, but many significant gaps in our knowledge of the schistosomal glycome remain. Here we will present a concise review of the already available data guided by a selection of recently generated stage-specific glycan profiles, and discuss implications and prospects of glycomics studies of schistosomes. |
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Keywords: | Schistosoma Glycoprotein Carbohydrate Host-parasite interaction Immunomodulation Antigen Glycome Glycan Lectin CAA, circulating anodic antigen CCA, circulating cathodic antigen CD, cluster of differentiation DC, dendritic cell DC-SIGN, dendritic cell-specific intercellular adhesion molecule-grabbing non-integrin HILIC, hydrophobic interaction liquid chromatography KLH, keyhole limpet hemocyanin LacNAc, N-acetyllactosamine LC, liquid chromatography LeX, Lewis X mAb, monoclonal antibody MALDI-TOF, matrix assisted laser desorption ionisation-time of flight MGL, macrophage galactose-binding lectin MR, mannose receptor MS, mass spectrometry PNGase, peptide-N-glycosidase SEA, soluble egg antigens TLR, toll-like receptor |
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