Premotor nonspiking neurons regulate coupling among motoneurons that innervate overlapping muscle fiber population |
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Authors: | Mariano Julián Rodriguez Carlos Bernardo Perez-Etchegoyen Lidia Szczupak |
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Institution: | (1) Dto de Fisiología, Biología Molecular y Celular, FCEN-UBA, IFIBYNE-CONICET, Buenos Aires, Argentina |
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Abstract: | Recent work indicated that co-activity of different motoneurons (MNs) in the leech can be regulated through a network that
is centered on a pair of nonspiking (NS) neurons. Here, we investigate whether this effect generalizes to different types
of MNs that display differential co-activity patterns in different motor behaviors: the dorsal longitudinal excitors DE-3
and the dorsal and ventral excitors MN-L. The data indicates that both motoneurons are coupled to the NS neurons through rectifying
junctions that are activated when the motoneuron membrane potential becomes more negative than that of the NS, and that they
exert an inhibitory synaptic potential on NS via a polysynaptic pathway. In addition, DE-3 and MN-L are linked by junctions
that allow mutual excitation but the transmission of excitatory signals from MN-L to DE-3 depended on NS membrane potential.
The results support the view that NS neurons can play a central role in orchestrating the co-activity of MNs during motor
behaviors. |
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Keywords: | Electrical coupling Motor circuits Leech Rectifying junctions Nonspiking neuron |
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