Adrenocorticotropic hormone-releasing activities of interleukins in a homologous in vivo system |
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| Authors: | Y Naito J Fukata T Tominaga Y Masui Y Hirai N Murakami S Tamai K Mori H Imura |
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| Affiliation: | Department of Anesthesia, Kyoto University Faculty of Medicine, Japan. |
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| Abstract: | We compared adrenocorticotropin-releasing activities of several interleukins in a homologous or heterologous in vivo system. Intravenous injection of rat interleukin-1 alpha significantly increased plasma adrenocorticotropin in conscious, freely-moving rats 30 min after the injection, and the effect was 10 times greater than that of human interleukin-1 alpha. Rat interleukin-2 affected plasma adrenocorticotropin in a much slower manner and increased its levels significantly 120 min after the injection. Human interleukin-2 had no effect on plasma adrenocorticotropin. Thus, species difference in the experimental system should be considered to assess the physiological significance of cytokines in the neuroendocrine system. |
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