Identification of a key structural feature of cobalt(III)-bleomycins: an exogenous ligand (e.g. hydroperoxide) bound to cobalt |
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Authors: | C H Chang J L Dallas C F Meares |
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Institution: | 1. Department of Chemistry University of California, Davis, California 95616 USA;2. Department of Biological Chemistry University of California, Davis, California 95616 USA |
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Abstract: | A series of cobalt(III) complexes of the anticancer antibiotic bleomycin has been prepared. Mass spectrometry and enzymatic analysis show that the green cobalt-bleomycin complex contains a hydroperoxide (-OOH) group bound to cobalt with unusual stability. Under appropriate conditions, cobalt-bleomycins containing other monodentate ligands to cobalt can be formed; fast-atom bombardment mass spectra of such complexes show peaks for cobalt-bleomycin at the expected mass, and also peaks for the intact complexes at the required higher mass. |
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Keywords: | BLM bleomycin Co(III)-BLM a cobalt(III)-bleomycin complex |
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