Synthesis and evaluation of 9,9-dimethylxanthene tricyclics against trypanothione reductase, Trypanosoma brucei, Trypanosoma cruzi and Leishmania donovani |
| |
Authors: | Chibale K Visser M Yardley V Croft S L Fairlamb A H |
| |
Affiliation: | Department of Chemistry, University of Cape Town, South Africa. chibale@psipsy.uct.ac.za |
| |
Abstract: | Derivatives of 9,9-dimethylxanthene were synthesised and evaluated against trypanothione reductase (TR) and in vitro against parasitic trypanosomes and leishmania. High in vitro antiparasitic activity was observed for some derivatives with one compound showing high activity against all three parasites (ED50 values of 0.02, 0.48 and 0.32 microM, for Trypanosoma brucei, Trypanosoma cruzi, and Leishmania donovani, respectively). The lack of correlation between inhibitory activity against TR and ED50 values suggests that TR is not the target. |
| |
Keywords: | |
本文献已被 ScienceDirect PubMed 等数据库收录! |
|