The direct toxicity of alpha-naphthylisothiocyanate in cell culture |
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| Authors: | G M Williams |
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| Institution: | Department of Pathology and Fels Research Institute, Temple University School of Medicine, Philadelphia, Pa., 19140 U.S.A. |
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| Abstract: | α-naphthylisothiocyanate (ANIT) kills rat liver cells in culture. Testing of a variety of related compounds revealed that toxicity depended upon the isothiocyanate group. The toxicity of ANIT was similar on several lines of cultured cells and in the presence of inhibitors and inducers of microsomal enzyme systems. The addition of a microsomal metabolizing system from rat liver to the cell cultures greatly enhanced the toxicity of 2 hepatotoxins requiring metabolism, but did not affect the toxicity of ANIT. It is concluded therefore that ANIT is toxic without biotransformation. |
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| Keywords: | ANIT α-naphthylisothiocyanate ARL adult rat liver DMN dimethylnitrosamine DMSO dimethylsulfoxide |
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