Synthesis, cytotoxic evaluation, and DNA binding of novel thiazolo[5,4-b]quinoline derivatives |
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Authors: | Loza-Mejía Marco A Maldonado-Hernández Karina Rodríguez-Hernández Fernando Rodríguez-Sotres Rogelio González-Sánchez Ignacio Quintero Angelina Solano José D Lira-Rocha Alfonso |
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Affiliation: | Departamento de Farmacia, Facultad de Química, Universidad Nacional Autónoma de México, Cd. Universitaria, Coyoacán, México 04510, Mexico. |
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Abstract: | A series of novel alkylamino and 9-anilinothiazolo[5,4-b]quinolines were synthesized as potential antitumoral agents. The in vitro cytotoxicity of these compounds was evaluated on several cell lines. The inclusion of electron-withdrawn/acceptor hydrogen-bond groups at position 3' of the anilino ring and the presence of an alkylamino chain on the tricyclic framework (regardless of its position) seem to be structural features relevant to cytotoxic activity. |
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