MCH-R1 antagonists based on an arginine scaffold: SAR studies on the amino-terminus |
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Authors: | Méndez-Andino José Colson Anny-Odile Denton Daniel Mitchell Maria C Cross-Doersen Doreen Hu X Eric |
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Affiliation: | Procter & Gamble Pharmaceuticals, 8700 Mason-Montgomery Road, Mason, OH 45039, USA. mendezandino.jl@pg.com |
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Abstract: | We have identified a novel series of potent MCH-R1 antagonists based on l-arginine. As predicted by computational methods, there was an activity dependence on the pi-electronic character of the aromatic systems corresponding to the amino-terminus of these molecules. These results have enhanced our understanding of the MCH-R1 receptor and the potential for a predictive homology model. |
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