Synthesis of C-5'-alkyl substituted 17-spirofuran 19-norsteroids |
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| Authors: | Khripach V A Zhabinskii V N Tsavlovskii D N Drachenova O A Ivanova G V Konstantinova O V Zavadskaya M I Lyakhov A S Govorova A A Groen M B de Groot A |
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| Institution: | Institute of Bioorganic Chemistry, National Academy of Sciences of Belarus, Kuprevich str., 5/2, 220141, Minsk, Belarus. khripach@ns.iboch.ac.by |
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| Abstract: | A number of new steroidal 17-spirofuran derivatives of the 19-nor series containing Me, Et or (i)Pr-substituents in the heterocyclic moiety has been prepared, which are expected to have a strong progestagenic activity. The proposed approach made use of the 1-3-dipolar cycloaddition of low-molecular nitrile oxides with steroidal acetylenic alcohols followed by transformation of the isoxazole side chain. |
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