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瑞舒伐他汀治疗颈动脉粥样硬化斑块的临床研究
引用本文:刘玉昊 王晶 王旭 邵一兵 许文亮 惠波 武越. 瑞舒伐他汀治疗颈动脉粥样硬化斑块的临床研究[J]. 现代生物医学进展, 2012, 12(1): 123-125
作者姓名:刘玉昊 王晶 王旭 邵一兵 许文亮 惠波 武越
作者单位:1. 青岛市市立医院东院区心内科 山东青岛266071
2. 青岛市市立医院东院区呼吸内科 山东青岛266071
摘    要:目的:研究瑞舒伐他汀对颈动脉粥样硬化斑块的治疗效果。方法:将在本院接受治疗的250例颈动脉粥样硬化斑块患者随机分成治疗组125例和对照组125例,治疗组服用瑞舒伐他汀10mg/晚,对照组行其他非瑞舒伐他汀药物治疗,进行为期6个月的观察对比。结果:治疗组治疗后总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白(LDL)水平显著下降,高密度脂蛋白(HDL)水平显著升高(P<0.05),颈动脉内膜-中层厚度(IMT)、斑块面积变小,与治疗前比较,差异有统计学意义(P<0.05);对照组治疗前后无显著性差异(P>0.05)。结论:瑞舒伐他汀对降低血脂、减缓不稳定型心绞痛早期动脉粥样硬化、稳定斑块和预防脑血管疾病起到非常重要的作用。

关 键 词:瑞舒伐他汀  颈动脉粥样硬化  临床研究

Clinical Research of Rosuvastatin in Treating Carotid Atherosclerosis Plaque
LIU Yu-hao,WANG Jing,WANG Xu,SHAO Yi-bing,XU Wen-liang,HUI Bo,WU Yue. Clinical Research of Rosuvastatin in Treating Carotid Atherosclerosis Plaque[J]. Progress in Modern Biomedicine, 2012, 12(1): 123-125
Authors:LIU Yu-hao  WANG Jing  WANG Xu  SHAO Yi-bing  XU Wen-liang  HUI Bo  WU Yue
Affiliation:1(1 Department of Cardiology,East Branch of Qingdao Municipal Hospital;2 Department of Respiration,East Branch of Qingdao Municipal Hospital,260071,Qingdao,China)
Abstract:Objective: To investigate the effects of rosuvastatin on carotid atherosclerosis plaque.Methods: A total of 250 patients with carotid atherosclerosis plaque who were therapied in our hospital average randomly divided into two groups: rosuvastatin group(n=125) and routine therapy control group(control group,n=125).Rosuvastatin group was given rosuvastatin in 10mg per night,routine therapy control group was given treatment without rosuvastatin.Two groups both were evaluated for 6 months.Results: The levels of TC,TG and LDL of rosuvastatin group after treatment decreased significantly,HDL increased.IMT and area of carotid atherosclerotic plaque decreased significantly.There was statistical significance between pretreatment and post-treatment in the rosuvastatin group(P<0.05),but there was no obvious change in the control group(P>0.05).Conclusion: Rosuvastatin can lower blood-lipid level and prevent the progres-sion of early atherosclerotic plaque of unstable angina.At the same time it improves the stabilization of plaque and plays an active role in prevention of cerebral vascular disease.
Keywords:Rosuvastatin  Carotid atherosclerosis plaque  Clinical research
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