甲状腺疾病对孕妇及胎儿的影响

目的:甲状腺功能障碍是孕期比较常见的内分泌疾病,本次研究的主要目的是找出孕期最常见的甲状腺功能障碍以及对孕妇及胎儿的影响及结果。方法:回顾性分析我院2006年1月1日至2009年1月1日在我院行产前保健的中孕期孕妇1000例。详细记录各项检查结果,TSH水平检测,TSH筛查异常的孕妇测定其游离T4水平并详细记录直至胎儿出生。结果:甲状腺功能障碍孕期比较常见,其中孕妇合并亚临床甲状腺功能减退(6.40%)和临床甲状腺功能减退(4.40%)最为常见,合并临床甲状腺机能减退症的产妇更容易发生妊娠期高血压(20.5%)和TUGR(13.6%),患有亚临床甲状腺机能减退症和亚临床甲状腺机能亢进症的产妇发生贫血的几率比较大,分别为14.1%和22.2%,并且有统计学意义。临床甲状腺机能亢进的产妇发生妊娠期糖尿病的风险明显增高33.3%,亚临床甲状腺机能减退症的产妇因胎儿宫内窘迫而行剖宫产的几率明显增高(23.4%,p<0.05),而且发生早产的风险同样增加9.4%。结论:甲状腺功能障碍孕期常见,尤其是及亚临床甲状腺功能减退(6.40%)。对孕妇及胎儿的不利影响比较明显,孕前检测甲状腺功能极为必要。

Thyroid Dysfunction Among Pregnant Women and its Effect On Maternal and Fetal Outcome

Objectives: Thyroid function disorders are common endocrine diseases in the duration of pregnancy.This study aims to define the most frequently occurred thyroid dysfunction in pregnancy and analyze the influences upon the mother and baby.Methods:Comprehensively review and analyze the 1000 cases in mid-gestation who came for prenatal examination.The clinical data such as the level of THS and dissociative T4 were recorded and analyzed respectively until they gave the delivery.Results: Thyroid function disor-ders are common in the duration of pregnancy,in which sub-clinical(6.4%)and clinical thyroid disorder(4.4%) are the most common.Parturient suffered from clinical thyroid disorder are more predisposing to gestational-period hypertension(20.5%) and TUGR(13.6%).Parturient suffered from sub-clinical thyroid disorder are more predisposing to anemia,14.1% in sub-clinical hypothyrea and 22.2% in sub-clinical hyperthyroidism(p<0.05).What’s more,parturient with clinical hyperthyroidism have higher risk of diabetes mellitus(33.3%) Parturient suffered from sub-clinical thyroid disorder are more predisposing to uterine-incision delivery(23.4%,p<0.05)because of uterus anoxia,with a higher risk of prematurity(9.4%).Conclusion: Thyroid function disorders are common endocrine diseases in the duration of pregnancy,especially sub-clinical thyroid disorder(6.4%) which has negative effects on the mother and baby.Therefore,it’s essential to monitor the thyroid function before pregnancy.