新疆维族妇女感染的HPV 型别分布的研究

目的:探讨人乳头瘤状病毒(Human papillomavirus,HPV)在新疆南部维族妇女人群中的型别分布情况。方法:以年龄在30-59岁的新疆伽师县夏普吐勒乡维吾尔族妇女人群为基础进行筛查,签署知情同意书后,采集受试者宫颈脱落细胞,利用PCR和基因芯片技术检测HPV DNA并分型。结果:共2473名妇女入选。HPV总的感染率为9.1%,高危型中HPV-16的感染率最高为6.9%,其他高危型的感染率从高到低依次为:HPV-59、HPV-56、HPV-18、HPV-33、HPV-58、HPV-51、HPV-31、HPV-45、HPV-52、HPV-68、HPV-35、HPV-39。低危型中HPV11感染率最高,其他低危型的感染率从高到低依次为HPV-42、HPV-43、HPV-6、HPV-53、HPV-66、HPV-73。HPV-44、-83、-MM4没检测到。多重感染率为34.2%。结论:新疆维吾尔族妇女人群中以HPV16感染为主,其次为HPV59、56、18、33等。HPV59可能是新疆维吾尔族妇女较易感染的类型。体现了新疆维吾尔族妇女感染HPV的特殊性。

Distribution and Prevalence of Human Papillomavirus (HPV) Genotypes in 2473 Cytological Samples Of Xinjiang Uyghur Women

Objective: To investigate the types distribution of human papillomavirus(HPV) in women in Xinjiang Uyghur women.Methods: Women between 30 and 59 were chosen in cluster stratified sampling from XiaPuTaoLe Town,Xinjiang and received a popu-lation-based cervical cancer screening.After consent,every woman was detected and genotyped HPV DNA by PCR and Gene Chip.Results: 2473 women were chosen.The total infection rate of HPV was 9.1%.The positive rate of HPV-16 infection was 6.9% among the High-Risk HPV indicating it was the most common infection.Other High-Risk HPV infection rates were ranked from high to low: HPV-59,HPV-56,HPV-18,HPV-33,HPV-58,HPV-51,HPV-31,HPV-45,HPV-52,HPV-35,HPV-39,HPV-68.HPV-11 was the most com-mon infection among the Low-Risk HPV types.Other Low-Risk HPV infection rates were ranked from high to low: HPV-42,HPV-43,HPV-6,HPV-53,HPV-66,HPV-73.HPV-44,-83,-MM4 were not detected.The multiple infection rate was 34.2%.Conclusion: HPV-16 was the most common types in the study population.The next most common types of HPV were HPV59,56,18,33.Xinjiang Uighur women had the relatively higher risk of suffering HPV59 infection indicating the specificity of HPV infection in Xinjiang Uighur women.