抑癌基因p53 在肝癌组织中的异常表达及临床意义

目的:探讨抑癌基因p53在肝癌组织中表达及临床意义,为肝癌的治疗提供新的思路。方法:回顾性分析了2006年1月～2009年8月收治的40例肝癌患者的临床资料,采用免疫组织化学法测定肝癌组织、癌旁组织和正常组织中抑癌基因p53的表达,并分析不同肿瘤分化程度患者p53的表达。结果:p53阳性表达率在在肝癌组、癌旁组分别为47.5%和2.5%,在正常组未检测到p53阳性表达,三组之间比较有显著性差异(x2=6.515,P=0.024);高分化癌P53蛋白阳性表达率低,中低分化癌P53蛋白阳性表达率高,组比较均有显著性差异(P<0.05),中、低分化组之间比较差异无统计学意义(P>0.05)。结论:在肝癌组织中存在p53基因的高表达,其阳性表达与肿瘤分化程度有关。

Abnormal Expression of Tumor Suppressor Gene P53 in HepatocellularCarcinoma and its Clinical Significance

Objective: To investigate the abnormal expression of tumor suppressor gene p53 in hepatocellular carcinoma and its clinical significance.Methods: The clinical data of patients with pimary liver cancer was retrospectively analyzed from January 2006 to August 2009.The p53 expression in hepatocellular carcinoma,cancer tissue and normal tissue was detected by immunohistochemistry method,and the p53 expression were analyzed in different degree of tumor differentiation.Results: The p53 expression rate in liver cancer group and the adjacent group were 47.5% and 2.5%,respectively.There was no p53 expression in the normal group.The difference among the three groups were significant(x2=6.515,P=0.024).The positive expression rate of p53 in well-differentiated carcinoma was low,but the positive expression of p53 in moderately and poorly differentiated carcinoma was high;the difference was significant(P<0.05).The difference was not significant between moderately and poorly differentiated carcinoma(P> 0.05).Conclusions: The tumor suppressor gene p53 has high expression in the liver cancer,and its expression is related to degree of tumor differentiatio.