Identification of latexin by a proteomic analysis in rat normal articular cartilage |
| |
| Authors: | Elizabeth Pérez José L Gallegos Leticia Cortés Karla G Calderón José C Luna Febe E Cázares María C Velasquillo Juan B Kouri Fidel C Hernández |
| |
| Affiliation: | 1.Departamento de Infectómica y Patogénesis Molecular, Centro de Investigación y de Estudios Avanzados,Instituto Politécnico Nacional (CINVESTAV-IPN),México;2.División de Investigación en Salud, Hospital de Ortopedia, "Dr. Victorio de la Fuente Narváez",Instituto Mexicano del Seguro Social (IMSS),México;3.Unidad de Proteómica Médica,Instituto Nacional de Medicina Genómica (INMEGEN),México;4.Departamento de Fisiología y Unidad de Microscopia Confocal,CINVESTAV-IPN,México;5.Unidad de Ingenería de Tejidos, Terapia Celular y Medicina Regenerativa,Instituto Nacional de Rehabilitación (INR),México |
| |
| Abstract: | Background Osteoarthritis (OA) is characterized by degeneration of articular cartilage. Animal models of OA induced are a widely used tool in the study of the pathogenesis of disease. Several proteomic techniques for selective extraction of proteins have provided protein profiles of chondrocytes and secretory patterns in normal and osteoarthritic cartilage, including the discovery of new and promising biomarkers. In this proteomic analysis to study several proteins from rat normal articular cartilage, two-dimensional electrophoresis and mass spectrometry (MS) were used. Interestingly, latexin (LXN) was found. Using an immunohistochemical technique, it was possible to determine its localization within the chondrocytes from normal and osteoarthritic articular cartilage. |
| |
| Keywords: | |
| 本文献已被 SpringerLink 等数据库收录！ |
|
