Relationship of F9 antigen and genes of theT/t complex |
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Authors: | Patricia Marticorena Karen Artzt Dorothea Bennett |
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Affiliation: | (1) Laboratory for Developmental Genetics, Sloan-Kettering Institute for Cancer Research, 10021 New York, New York |
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Abstract: | Serological studies relating F9 antigen of embryonal carcinoma cells to at the murineT/t complex have been extended and confirm that only the lethal haplotype t12- and none of the other five lethal haplotypes-affects the quantitative expression of F9 antigen on sperm. Cytotoxicity tests on preimplantation embryos show that t12 homozygotes are less susceptible to antiF9 serum than tw5 homozygotes, and that using specific antimutant haplotype antisera prepared against sperm, t12 antigen is detectable on morulae, whereas tw5 antigen is not. |
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