Evidence that glutathione participates in the induction of a stress protein |
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| Authors: | K R Shelton P M Egle J M Todd |
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| Affiliation: | 1. Division of Urology, Department of Surgery, University of Texas McGovern Medical School at Houston, Houston, TX, USA;2. Scott Department of Urology, Baylor College of Medicine, Houston, TX, USA;3. Division of Urology, Department of Surgery, University of Utah School of Medicine, Salt Lake City, UT, USA;1. Department of Pharmaceutical Sciences, Guru Nanak Dev University, Amritsar, Punjab, India, 143005;2. Drug and Pollution testing Lab, Guru Nanak Dev University, Amritsar, Punjab, India, 143005;3. Drugs Control Wing, Sector 16, Chandigarh, India, 160015;4. School of Pharmacy, Desh Bhagat University, Mandi Gobindgarh, Punjab, India, 147301 |
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| Abstract: | A step in the induction of a 30- to 35-kD stress protein may be the reaction of chemical inducers with glutathione. Effective inducers are sulfhydryl reagents. Further, a comparison of three reagents, 1-chloro-2,4-dinitrobenzene, diethylmaleate, and N-ethylmaleimide, indicates that the first two, which have considerable selectivity for glutathione, are strong inducers of the stress protein but the third, which is much more reactive with protein sulfhydryls, is either a poor or ineffective inducer. A decrease in cellular glutathione does not appear to be inductive, however. An increase in modified glutathione remains as a possible signal for the induction of this stress protein. |
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