A new prostaglandin E1 analogue (TFC-612) prevents a decrease in motor nerve conduction velocity in streptozocin-diabetic rats |
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| Authors: | H Yasuda M Sonobe I Hatanaka M Yamashita Y Miyamoto M Terada M Amenomori R Kikkawa Y Shigeta Y Motoyama |
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| Institution: | Third Department of Medicine, Shiga University of Medical Science, Japan. |
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| Abstract: | A new prostaglandin E1 analogue (TFC-612) was orally given to streptozocin-diabetic rats for 4 weeks after the induction of diabetes and its effects on motor nerve conduction velocity were studied. The compound significantly prevented a decrease of the velocity but did not reverse abnormal sorbitol and myo-inositol contents of the sciatic nerve. The results suggest that TFC-612 has a potent effect on diabetic nerve dysfunction via other mechanism than the correction of sorbitol and myo-inositol metabolisms and could be a potential compound for therapy of diabetic polyneuropathy. |
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