1H-N.M.R. spectra of glycosaminoglycan monomers and dimers in solution in methyl sulphoxide and water |
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| Authors: | Frank Heatley John E. Scott Benito Casu |
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| Affiliation: | Department of Chemistry, University of Manchester, Oxford Road, Manchester M13 9PT Great Britain;Department of Medical Biochemistry, University of Manchester, Oxford Road, Manchester M13 9PT Great Britain;G. Ronzoni Institute, 20133 Milan Italy |
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| Abstract: | 1H-N.m.r. spectra of glycosaminoglycuronan monomers and dimers in solution in methyl sulphoxide-d6 have been investigated; N-H and O-H resonances were observed and partially assigned. Their temperature-dependence suggests hydrogen-bonding to the solvent, with the notable exception of that of HO-4 Of sodium D-gluctironate, which was consistently downfield and relatively temperature-insensitive. The concentration-dependence ofthis signal indicates that the corresponding hydroxyl group is involved in the formation of a dimer. Signals for N-H and O-H were observed for aqueous solutions, especially at subzero temperatures. |
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| Keywords: | To whom requests for reprints should be sent. |
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