Moments of physiological transit time distributions and the time course of drug disposition in the body |
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Authors: | M Weiss |
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Institution: | (1) Institute of Pharmacology and Toxicology, Martin Luther University Halle-Wittenberg, Leninallee 4, DDR-402 Halle (Saale), German Democratic Republic |
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Abstract: | Characterizing the tissue distribution kinetics of drugs by physiological and physico-chemical parameters and using a circulatory model the time course of blood concentration after intravenous injection is predicted for linear pharmacokinetic systems. The interrelationships between the first three (zero to second) moments of the distribution functions of organ transfer times, circulation times and residence times of drug molecules in the body are described. Utilizing literature data the model is applied to the analysis of lidocain kinetics in humans. |
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Keywords: | Pharmacokinetics Linear recirculatory model Tissue distribution process Transit time |
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