Stimulation of tyrosine phosphorylation of rat brain membrane proteins by calmodulin |
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| Authors: | D F Michiel J H Wang |
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| Affiliation: | Cell Regulation Group, Department of Medical Biochemistry, The University of Calgary, Calgary, Alberta T2N 4N1, Canada |
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| Abstract: | Calmodulin stimulates the alkali-resistant phosphorylation of peptides of 50 and 58-60 kDa in rat brain membrane. Phosphoamino acid analysis indicated a calmodulin stimulated increase of phosphotyrosine in these peptides. Calmodulin also stimulated the phosphorylation of these peptides at serine and threonine residues. This suggests the involvement of the calmodulin regulatory system in the effects of tyrosine protein kinases. |
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