The role of alpha-2u-globulin in corticosteroidogenesis in male rats |
| |
Authors: | P K Ghosh N M Biswas |
| |
Affiliation: | Department of Physiology, University Colleges of Science and Technology, Calcutta, India. |
| |
Abstract: | Administration of estradiol-17 beta for 7 days to the adult male rat results in adrenal hyperplasia, decreased serum corticosterone along with elevation in serum ACTH and inhibition of adrenal 5-ene-3 beta-hydroxysteroid dehydrogenase activity (5-ene-3 beta-HSD). Treatment with alpha 2u-globulin for following 14 days of estrogen-treated rats reversed the effects of estrogen while in normal rats alpha 2u-globulin treatment increased adrenal 5-ene-3 beta-HSD activity and serum corticosterone level while causing a fall in serum ACTH. It is concluded that alpha 2u-globulin may play a role in ACTH secretion by inducing corticosterone synthesis. |
| |
Keywords: | |
|
|