Effects of acrolein on the quadruplex forming d(TTAGGG)4 telomeric repeat sequence |
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| Authors: | Borbone Nicola D'Isa Giuliana Oliviero Giorgia Piccialli Gennaro Varra Michela Mayol Luciano |
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| Institution: | Dipartimento di Chimica delle Sostanze Naturali, University of Naples, Faculty of Pharmacy, via Domenico Montesano 49, Napoli 80131, Italy. borbone@unina.it |
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| Abstract: | HPLC and ESI-MS analysis have been used to investigate the effect of acrolein exposure on d(TITAGGG)4 human telomeric repeat. Preliminary results disclosed a novel relationship between the structure assumed by oligodeoxynucleotides (ODNs) and the capability of their nucleobase residues to react with acrolein. |
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