Oxidised glutathione reductase activity in mouse epidermis: TPA induced change and its modulation by vitamin A |
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Authors: | S Kumar M Antony N K Mehrotra |
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Affiliation: | Laboratory of Industrial & Environmental Carcinogenesis Industrial Toxicology Research Centre, P.B. No.80, Mahatma Gandhi Marg, Lucknow-226001, India |
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Abstract: | Single cutaneous application of 12-O-tetradecanoyl-phorbol-13-acetate (TPA) increased epidermal oxidised glutathione reductase activity in adult mouse by almost 100%. Pretreatment of animals with vitamin A for a week resulted in 75% inhibition of TPA induced change in the enzyme activity which remained unaffected in skin treated with vitamin A alone. This biochemical change in skin induced by TPA and modulated by vitamin A has been discussed in relation to epidermal hyperplasia. |
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