Apoptosis in mouse fetal and neonatal oocytes during meiotic prophase one |
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| Authors: | Fataneh Ghafari Carlos G Gutierrez Geraldine M Hartshorne |
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| Affiliation: | (1) Department of Biological Sciences, University of Warwick, Coventry, CV4 7AL, UK;(2) Facultad de Medicina Veterinaria, Universidad Nacional Autonoma de Mexico, DF 04510 Mexico, Mexico;(3) Clinical Sciences Research Institute, Warwick Medical School, University of Warwick, Coventry, CV2 2DX, UK;(4) Centre for Reproductive Medicine, University Hospitals Coventry and Warwickshire NHS Trust, Coventry, CV2 2DX, UK |
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| Abstract: | Background The vast majority of oocytes formed in the fetal ovary do not survive beyond birth. Possible reasons for their loss include the elimination of non-viable genetic constitutions arising through meiosis, however, the precise relationship between meiotic stages and prenatal apoptosis of oocytes remains elusive. We studied oocytes in mouse fetal and neonatal ovaries, 14.5–21 days post coitum, to examine the relationship between oocyte development and programmed cell death during meiotic prophase I. |
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