Assisted Reproductive Technology affects developmental kinetics, <Emphasis Type="Italic">H19</Emphasis> Imprinting Control Region methylation and <Emphasis Type="Italic">H19</Emphasis>gene expression in individual mouse embryos |
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| Authors: | Patricia Fauque Pierre Jouannet Corinne Lesaffre Marie-Anne Ripoche Luisa Dandolo Daniel Vaiman Hélène Jammes |
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| Institution: | 1.Biologie de la Reproduction, H?pital Cochin,AP-HP, Université Paris Descartes,Paris,France;2.Génétique et Développement,INSERM Institut Cochin U567, CNRS (UMR 8104), Université Paris Descartes,Paris,France;3.Genetics Department, INRA,Jouy en Josas,France;4.PHASE Department, INRA,Jouy en Josas,France |
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| Abstract: | Background In the last few years, an increase in imprinting anomalies has been reported in children born from Assisted Reproductive Technology
(ART). Various clinical and experimental studies also suggest alterations of embryo development after ART. Therefore, there
is a need for studying early epigenetic anomalies which could result from ART manipulations, especially on single embryos.
In this study, we evaluated the impact of superovulation, in vitro fertilization (IVF) and embryo culture conditions on proper genomic imprinting and blastocyst development in single mouse
embryos. |
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