Inhibition of DNA polymerase from herpes simplex virus-infected wi-38 cells by phosphonoacetic Acid |
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| Authors: | Mao J C Robishaw E E Overby L R |
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| Affiliation: | Abbott Laboratories, North Chicago, Illinois 60064. |
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| Abstract: | Infection of Wi-38 cells with herpes simplex virus induced an elevated DNA polymerase activity which had many biochemical properties different from normal cell DNA polymerase. Phosphonoacetic acid specifically inhibited the virus-induced DNA polymerase as compared to the normal WI-38 cell DNA polymerase. The compound did not appear to inhibit enzyme activity by interacting with the DNA primer. |
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