Synthesis of imidazo[1,5,4-de]quinoxalin-9-ones, benzimidazole analogues of pyrroloiminoquinone marine natural products |
| |
Authors: | Labarbera Daniel V Skibo Edward B |
| |
Institution: | Department of Chemistry and Biochemistry, Arizona State University, Tempe, AZ 85287-1604, USA. |
| |
Abstract: | The imidazoquinoxalinones 1 and 2 are benzimidazole analogues of indole-based marine natural products called makaluvamins. The stabilized cation 1 and the zwitterion 2 were prepared in approximately 9 steps from readily available starting materials. Compound 1 is more cytostatic and cytotoxic than 2 and also shows activity in the hollow fiber assay. Unlike the indole-based natural products, 1 and 2 are not potent topoisomerase II inhibitors. Their pattern of cytotoxic and cyostatic activity could be related to inhibition of protein tyrosine kinases. |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |
|