Effective immunotherapy against cancer |
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Authors: | Email author" target="_blank">Karl-Johan?MalmbergEmail author |
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Institution: | (1) Center for Infectious Medicine (CIM), F59, Department of Medicine, Karolinska Institutet, Karolinska University Hospital Huddinge, S-14186 Stockholm, Sweden |
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Abstract: | During the last decade, the breakthroughs in understanding of the molecular mechanisms responsible for immune activation and the advent of recombinant DNA technologies have changed the view on immunotherapy from a dream scenario to becoming a clinical reality. It is now clear that both cellular immunity comprising T and NK cells, as well as strategies based on antibodies, can provide strong antitumoral effects, and evidence is emerging that these strategies may also cure patients with previously incurable cancers. However, there are still a number of issues that remain unresolved. Progress in immunotherapy against cancer requires a combination of new, improved clinical protocols and strategies for overcoming mechanisms of immune escape and tumor-induced immune suppression. This review discusses some of the salient issues that still need to be resolved, focusing on the role of oxidative stress and the use of antioxidants to alleviate the immune hyporesponsiveness induced by reactive oxygen species (ROS).Abbreviations HLA
Human leukocyte antigen - KIR
Killer cell immunoglobulin-like receptor - NKR
Natural killer cell receptor - ROS
Reactive oxygen species - TAA
Tumor-associated antigenThis work is part of the Symposium in Writing Tumor escape from the immune response, published in vol 53. |
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Keywords: | Immune escape Immune suppression Immunotherapy Oxidative stress |
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