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A study of X chromosome regulation during oogenesis in the mouse
Authors:R J Andina
Affiliation:Department of Genetics, University of Washington, Seattle, WA 98195, USA
Abstract:Mature oocytes of mammals, in contrast to somatic cells, have two active X chromosomes. This situation might arise through either of two possible mechanisms. The germ line might be differentiated from somatic cells prior to X inactivation. Alternatively, an X chromosome in germ cells would be reactivated after prior inactivation. This paper presents data compatible with reactivation of the X in germ cells. X-linked enzymes were compared in oocytes of XX and XO fetal mice. The activity of G6PD is similar in the two classes of cells at early meiotic stages, but an XXXO ratio of 2:1 is approached at later times; this suggests reactivation of the G6PD locus. For HPRT, a 2:1 ratio is observed at all meiotic stages. HPRT shows a large increase in enzyme activity during early meiosis, while G6PD does not. Synthesis of this enzyme at early meiotic stages probably accounts for differences between these data and those obtained for G6PD, and places the time of X reactivation at the entry to meiosis.
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