环境内分泌干扰物对生殖健康影响的研究进展

环境内分泌干扰物(environmental endocrine disruptors,EEDs)是指环境中天然存在或污染的能够干扰机体内自然激素的合成、分泌、转运、结合、作用和消除等过程,表现出拟自然激素或抗自然激素的生理学作用的一类化合物。它们与人们的生活密不可分,比如邻苯二甲酸酯类(PAEs)和双酚A(BPA),就广泛存在于食品包装、儿童玩具及生活用品中。大量实验证据以及流行病学的调查表明环境内分泌干扰物对动物雌激素、睾酮、甲状腺素、儿茶酚胺等呈现显著的干扰效应,是生殖障碍、出生缺陷、发育异常、代谢紊乱以及某些恶性肿瘤的发病率增加的原因之一。本文归纳了环境内分泌干扰物(EEDs)对生殖健康影响的研究进展。

The Research Progress on the Effect of the Reproductive Health by the Environmental Endocrine Disruptors

Environmental endocrine disruptors (EEDs) are a group of natural or polleted chemical compounds which are interfering with the synthesis, secretion, transport, metabolism, binding, action, and elimination of the natural endocrine hormones. Therefore, they can make an active or antagonistic effect in body. They are existing around us, such as PAEs and BPA. They appear in the food packaging, children''s toys and the articles for daily use. Many experimental evidences and epidemiological investigations demonstrate that EEDs make a remarkable interference effect on the estrogen, androgen, thyroxine and catecholamine. They are one of the reasons to be dysfunction in reproduction, birth defect, dysplasia, metabolic disorders and the increasing prevalence rate of cancer. This review makes a summary on the research progress of the effect that the Environmental endocrine disruptors make on the reproductive health.