235例浸润性乳腺癌中P53、ER的表达及其相关性探讨

目的:分析浸润性乳腺癌中P53和雌激素受体(estrogen receptor,ER)的表达及其与患者临床病理特征的关系和二者之间的相关性,探讨其在浸润性乳腺癌发生发展中的作用。方法:收集我院2008年至2013年6月收治的原发浸润性乳腺癌手术病例235例,采用免疫组化SP法检测乳腺癌组织标本中P53与ER的表达,分析其与患者临床病理特征的关系及二者之间的相关性。结果:本组乳腺癌组织中P53与ER的阳性表达率分别为31.9%及56.6%,均显著高于癌旁正常组织(P0.05)。乳腺癌组织中ER的表达仅与患者的年龄有关,与TNM分期无关;而P53的表达与患者的年龄和TNM分期均无关,但P53与ER的表达呈显著负相关(P0.05,r=-0.174)。结论:P53与ER在浸润性乳腺癌中均呈高表达,且二者呈显著负相关。

The Expression and Relationship between ER and P53 Expression inInvasive Breast Carcinoma

Objective:To analyze the correlation of ER, P53 expression with the clinicopathologic characteristics of patients withinvasive breast carcinoma and the correlation of ER expression with P53 expression, and to study the role of ER and P53in thetumorigenesis and development of invasive breast carcinoma.Methods:A total of 235 female cases with breast invasive carcinoma wereretrieved from the Department of Pathology Shanghai No.5 Hospital from 2008 to 2013. The immunohistochemical SP method was usedto detect the expression of ER and P53 in postoperative paraffin blocks. The correlation was analyzed between the clinicopathologiccharacteristics and ER, P53 expression, and between the ER expression and P53 expression. The expression of ER and P53 was observedinpericarcinous normal tissue.Results:The positive expression rates of ER and P53 were 56.6%and 31.9%in the 235 cases, which wereboth significantly higher than those of the adjacent normal breast tissue. The positive expression rate of P53 was negatively correlatedwith ER expression in the 235 cases (P<0.05, r= -0.174). Compared with the pericarcinousnormal tissue, the positive expression rate ofthe ER and P53 were significantly higher in the carcinoma tissue (P<0.05).Conclusion:The expression of P53 and ER were bothupregulated in invasive breast carcinoma, which were negatively correlated and may play an important role in the tumorigenesis ofinvasive breast carcinoma.