生物标志物在前列腺炎中的研究进展

前列腺炎是男性泌尿系统的常见疾病,由于前列腺炎存在病因和发病机制复杂,导致临床症状表现多种、药物治疗缺乏特异性和复发率较高等问题,因此前列腺炎的诊断、治疗和预后判断标准一直是临床关注的焦点。目前还没有诊断前列腺炎的"金标准",而生物标志物的检测有助于临床诊断、治疗和预后诊断,本文检索近年相关,对敏感性较高和特异性较好的一些前列腺炎生物标志物(细胞因子和趋化因子等)及今后研究的侧重点进行综述,从而为前列腺炎的诊断、分型治疗和预后观察提供依据。

Progress of Study on Biomarkers of Prostatitis

Prostatitis is a common genitourinary disease of adult male. Diagnosis, treatments and prognostic monitoring ofprostatitis have always been the focus of clinical attention, as a result of its setbacks, such as complex pathogenesis and clinicalsymptoms, lacking specificity in medication and its high rate of recurrence and so on. Currently, there isn''t a "golden standard" indiagnosis of prostatitis, while the detection of biomarkers can be helpful for the diagnosis, treatment and prognostic monitoring ofprostatitis. In this paper, we review the prostatitis biomarkers (cytokines/chemokine) which have high sensibility and good specificity, andalso, we review the future research emphasis. What we have studied may offer reference for diagnosis, treatment and prognosticmonitoring of prostatitis.