Immobility,inheritance and plasticity of shape of the yeast nucleus |
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| Authors: | Thomas Hattier Erik D Andrulis Alan M Tartakoff |
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| Institution: | (1) Cell Biology Program, Case Western Reserve University, 10700 Euclid Avenue, Cleveland, OH 44106, USA;(2) Department of Pathology, Case Western Reserve University, 10700 Euclid Avenue, Cleveland, OH 44106, USA;(3) Department of Molecular Biology and Microbiology, Case Western Reserve University, 10700 Euclid Avenue, Cleveland, OH 44106, USA |
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| Abstract: | Background Since S. cerevisiae undergoes closed mitosis, the nuclear envelope of the daughter nucleus is continuous with that of the maternal nucleus at
anaphase. Nevertheless, several constitutents of the maternal nucleus are not present in the daughter nucleus. The present
study aims to identify proteins which impact the shape of the yeast nucleus and to learn whether modifications of shape are
passed on to the next mitotic generation. The Esc1p protein of S. cerevisiae localizes to the periphery of the nucleoplasm, can anchor chromatin, and has been implicated in targeted silencing both at
telomeres and at HMR. |
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