|
|||||
|
|
Sialylation using N-glycolylneuraminyl phosphite donors to synthesize Neu5Gc-containing glycans |
|
| Authors: | Shinya Hanashima Taku Tomiya Shoji Akai |
| Institution: | a Material and Life Chemistry, Faculty of Engineering, Kanagawa University, 3-27-1 Rokkakubashi, Yokohama 221-8686, Japan b Structural Glycobiology Team, Systems Glycobiology Research Group, RIKEN Advanced Science Institutes, 2-1 Hirosawa, Wako-shi, Saitama 351-0198, Japan |
| Abstract: | Efficient sialylations using N-glycolylneuraminic acid (Neu5Gc) phosphite donors having an acetyl or benzyl group on the glycolyl moiety are described in the synthesis of Neu5Gc-containing glycans. Both phosphite donors 1 and 2 were readily coupled with primary and secondary acceptor alcohols in propionitrile at −78 °C to provide the desired glycosides with good α-selectivities. |
| Keywords: | N-Glycolylneuraminic acid Sialic acid Glycosylation Phosphite |
| 本文献已被 ScienceDirect 等数据库收录！ | |