Identification of a Linked Set of Genes in Serpulina hyodysenteriae (B204) Predicted To Encode Closely Related 39-Kilodalton Extracytoplasmic Proteins |
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| Authors: | Jeffrey D Gabe Elizabeth Dragon Ray-Jen Chang and Michael T McCaman |
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| Institution: | Point Biomedical, Inc., San Carlos, California 94070,1. Roche Molecular Systems, Inc., Branchburg, New Jersey 08876,2. and Process Development Department, Berlex Biosciences, Richmond, California 948043. |
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| Abstract: | A tandem pair of nearly identical genes from Serpulina hyodysenteriae (B204) were cloned and sequenced. The full open reading frame of one gene and the partial open reading frame of the neighboring gene appear to encode secreted proteins which are homologous to, yet distinct from, the 39-kDa extracytoplasmic protein purified from the membrane fraction of S. hyodysenteriae. We have designated these newly identified genes vspA and vspB (for variable surface protein). |
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