Peptidyl arginine deiminase type IV (PADI4) haplotypes interact with shared epitope regardless of anti-cyclic citrullinated peptide antibody or erosive joint status in rheumatoid arthritis: a case control study |
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| Authors: | So-Young Bang Tae-Un Han Chan-Bum Choi Yoon-Kyoung Sung Sang-Cheol Bae Changwon Kang |
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| Affiliation: | (1) Department of Rheumatology, Hanyang University Hospital for Rheumatic Diseases, 17 Hangdang-dong Seongdong-gu, Seoul, 133-792, South Korea;(2) Department of Biological Sciences, Korea Advanced Institute of Science and Technology, 335 Gwahangno Yuseong-gu, Daejeon, 305-701, South Korea |
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| Abstract: | Introduction Anti-cyclic citrullinated peptide autoantibodies (anti-CCP) are the most specific serologic marker for rheumatoid arthritis (RA). Genetic polymorphisms in a citrullinating (or deiminating) enzyme, peptidyl arginine deiminase type IV (PADI4) have been reproducibly associated with RA susceptibility in several populations. We investigated whether PADI4 polymorphisms contribute to anti-CCP-negative as well as -positive RA, whether they influence disease severity (erosive joint status), and whether they interact with two major risk factors for RA, Human Leukocyte Antigen-DRB1 (HLA-DRB1) shared epitope (SE) alleles and smoking, depending on anti-CCP and erosive joint status. |
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